Browsing by Subject "Viral Load"

Now showing items 1-10 of 10

    • Article  

      CCR5 promoter polymorphisms in a Kenyan perinatal human immunodeficiency virus type 1 cohort: Association with increased 2-year maternal mortality 

      John, G. C.; Bird, T.; Overbaugh, J.; Nduati, R.; Mbori-Ngacha, D.; Rostron, T.; Dong, T.; Kostrikis, Leontios G.; Richardson, B.; Rowland-Jones, S. L. (2001)
      The CCR5 chemokine receptor acts as a coreceptor with CD4 to permit infection by primary macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains. The CCR5Δ32 mutation, which is associated with resistance to ...
    • Article  

      Cellular HIV type 1 DNA levels are equivalent among drug-sensitive and drug-resistant strains in newly diagnosed and antiretroviral naive patients 

      Antoniadou, Zoi Anna; Hezka, Johana; Kousiappa, Ioanna; Mamais, Ioannis A.; Skoura, Lemonia G.; Pilalas, Dimitrios; Metallidis, Simeon A.; Nicolaidis, Pavlos; Malisiovas, Nikolaos; Kostrikis, Leontios G. (2014)
      The emergence of resistance against current antiretroviral drugs to human immunodeficiency virus type 1 (HIV-1) is an increasingly important concern to the continuous success of antiretroviral therapy to HIV-1-infected ...
    • Article  

      Cellular HIV-1 DNA levels in drug sensitive strains are equivalent to those in drug resistant strains in newly-diagnosed patients in Europe 

      Demetriou, Victoria L.; van de Vijver, D. A. M. C.; Kousiappa, Ioanna; Balotta, Claudia; Clotet, B.; Grossman, Z.; Jørgensen, L. B.; Lepej, S. Z.; Levy, I.; Nielsen, C.; Paraskevis, Dimitrios N.; Poljak, M.; Roman, F.; Ruiz, L.; Schmidt, J. -C; Vandamme, A. -M; van Laethem, K. V.; Vercauteren, J.; Kostrikis, Leontios G. (2010)
      Background HIV-1 genotypic drug resistance is an important threat to the success of antiretroviral therapy and transmitted resistance has reached 9% prevalence in Europe. Studies have demonstrated that HIV-1 DNA load in ...
    • Article  

      Cellular HIV-1 DNA load predicts HIV-RNA rebound and the outcome of highly active antiretroviral therapy 

      Hatzakis, Angelos E.; Touloumi, G.; Pantazis, N.; Anastassopoulou, C. G.; Katsarou, O.; Karafoulidou, A.; Goedert, J. J.; Kostrikis, Leontios G. (2004)
      Objective: To assess whether cellular HIV-1 DNA prior to highly active antiretroviral therapy (HAART) initiation predicts its outcome. Design and methods: Patients included all 51 hemophiliacs of the Greek component of the ...
    • Article  

      Changes in T Cell Receptor Excision DNA Circle (TREC) Levels in HIV Type 1-Infected Subjects Pre- and Post-Highly Active Antiretroviral Therapy 

      Touloumi, G.; Pantazis, N.; Karafoulidou, A.; Mandalaki, T.; Goedert, J. J.; Kostrikis, Leontios G.; Hatzakis, Angelos E. (2004)
      The T cell receptor excision DNA circle (TREC) level is an independent predictor of HIV-1 disease prognosis. We studied the temporal changes in TREC levels prior to and after highly active antiretroviral therapy (HAART) ...
    • Article  

      Effects of in Vivo CD8+ T cell depletion on virus replication in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine 

      Metzner, K. J.; Jin, X.; Lee, F. V.; Gettie, A.; Bauer, D. E.; Di Mascio, M.; Perelson, A. S.; Marx, P. A.; Ho, David D.; Kostrikis, Leontios G.; Connor, R. I. (2000)
      The role of CD8+ T lymphocytes in controlling replication of live, attenuated simian immunodeficiency virus (SIV) was investigated as part of a vaccine study to examine the correlates of protection in the SIV/rhesus macaque ...
    • Article  

      Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy 

      Sharkey, M. E.; Teo, I.; Greenough, T.; Sharova, N.; Luzuriaga, K.; Sullivan, J. L.; Bucy, R. P.; Kostrikis, Leontios G.; Haase, A.; Veryard, C.; Davaro, R. E.; Cheeseman, S. H.; Daly, J. S.; Bova, C.; Ellison III, R. T.; Mady, B.; Lai, K. K.; Moyle, G.; Nelson, M.; Gazzard, B.; Shaunak, S.; Stevenson, M. (2000)
      Treatment of HIV-1-infected individuals with a combination of anti- retroviral agents results in sustained suppression of HIV-1 replication, as evidenced by a reduction in plasma viral RNA to levels below the limit of ...
    • Article  

      Primary resistance to integrase strand-transfer inhibitors in Europe 

      Moutschen, M.; Casadellà, M.; van Ham, P. M.; Noguera-Julian, M.; van Kessel, A.; Pou, C.; Hofstra, Laura Marije Arije; Santos, J. R.; Garcia, F.; Struck, D.; Alexiev, Ivailo; Bakken Kran, A. M.; Hoepelman, A. I.; Kostrikis, Leontios G.; Somogyi, Sybille; Liitsola, K.; Linka, M.; Nielsen, C.; Otelea, D.; Paraskevis, Dimitrios N.; Poljak, M.; Puchhammer-Stöckl, E.; Staneková, D.; Stanojevic, M.; Van Laethem, K.; Zidovec Lepej, S.; Clotet, B.; Boucher, C. A. B.; Paredes, R.; Wensing, A. M. J.; Puchhammer-Stöckl, E.; Sarcletti, M.; Schmied, B.; Geit, M.; Balluch, G.; Vandamme, A. M.; Vercauteren, J.; Derdelinckx, I.; Sasse, A.; Bogaert, M.; Ceunen, H.; De Roo, A.; De Wit, S.; Echahidi, F.; Fransen, K.; Goffard, J. C.; Goubau, P.; Goudeseune, E.; Yombi, J. C.; Lacor, P.; Liesnard, C.; Pierard, D.; Rens, R.; Schrooten, Y.; Vaira, D.; Vandekerckhove, L. P.; Van den Heuvel, A.; Van Der Gucht, B.; Van Ranst, M.; Van Wijngaerden, E.; Vandercam, B.; Vekemans, M.; Verhofstede, C.; Clumeck, N.; Van Laethem, K.; Beshkov, Danail; Alexiev, Ivailo; Zidovec Lepej, S.; Begovac, J.; Demetriades, Ioannis; Kousiappa, Ioanna; Demetriou, Victoria L.; Hezka, Johana; Linka, M.; Machala, L.; Maly, M.; Nielsen, C.; Jørgensen, L. B.; Gerstoft, J.; Mathiesen, L.; Pedersen, C.; Nielsen, H.; Laursen, A.; Kvinesdal, B.; Liitsola, K.; Ristola, M.; Suni, J.; Sutinen, J.; Hamouda, O.; Kücherer, C.; Berg, T.; Braun, P.; Poggensee, G.; Däumer, M.; Eberle, J.; Heiken, H.; Kaiser, R.; Knechten, H.; Korn, K.; Müller, H.; Neifer, S.; Schmidt, B.; Walter, H.; Gunsenheimer-Bartmeyer, B.; Harrer, T.; Paraskevis, Dimitrios N.; Hatzakis, Angelos E.; Magiorkinis, Emmanouil N.; Hatzitheodorou, Eleni; Haida, Catherine; Zavitsanou, Assimina; Magiorkinis, Gkikas; Lazanas, Marios C.; Chini, Maria C.; Magafas, N.; Tsogas, Nickolaos; Paparizos, Vassilios A.; Kourkounti, Sofia; Antoniadou, Anastasia C.; Papadopoulos, Antonios I.; Panagopoulos, Periklis; Poulakou, Garyphallia G.; Sakka, V.; Chryssos, Georgios; Drimis, Stylianos; Gargalianos, Panagiotis; Lelekis, Moyssis I.; Chilomenos, G.; Psichogiou, Mina A.; Daikos, George L.; Sabatakou, H.; Panos, George; Haratsis, G.; Kordossis, Theodore; Kontos, Athanasios N.; Koratzanis, Georgios; Theodoridou, Maria C.; Mostrou, Glykeria J.; Spoulou, Vana I.; Schmit, J. C.; Struck, D.; Hemmer, R.; Arendt, V.; Staub, T.; Schneider, F.; Roman, F.; Wensing, A. M.; Boucher, C. A.; van de Vijver, D. A.; van Kessel, A.; van, P. H.; Brinkman, K.; Op de, E. L.; van der Ende, M. E.; Hoepelman, I. M.; van Kasteren, M.; Juttmann, J.; Kuipers, M.; Langebeek, N.; Richter, C.; Santegoets, R. M.; Schrijnders-Gudde, L.; Schuurman, R.; van de Ven, B. J.; Åsjö, Birgitta; Bakken, A. M.; Ormaasen, V.; Aavitsland, P.; Otelea, D.; Paraschiv, S.; Tudor, A. M.; Jevtovic, D.; Salemovic, D.; Stanekova, D.; Habekova, M.; Mokráš, Miloš; Truska, P.; Poljak, M.; Lunar, M.; Babic, Dunja Z.; Tomazic, J.; Vidmar, L.; Vovko, T.; Karner, P.; Clotet, B.; Garcia, F.; Domingo, P.; Galindo, M. J.; Miralles, C.; Del, M. A.; Ribera, E.; Iribarren, J. A.; Ruiz, L.; de la Torre, J.; Vidal, F.; Garcia, F.; Paredes, R. (2015)
      Objectives: The objective of this study was to define the natural genotypic variation of the HIV-1 integrase gene across Europe for epidemiological surveillance of integrase strand-transfer inhibitor (InSTI) resistance. ...
    • Article  

      Quantitation of human immunodeficiency virus type 1 DNA forms with the second template switch in peripheral blood cells predicts disease progression independently of plasma RNA load 

      Kostrikis, Leontios G.; Touloumi, G.; Karanicolas, R.; Pantazis, N.; Anastassopoulou, C. G.; Karafoulidou, A.; Goedert, J. J.; Hatzakis, Angelos E. (2002)
      There are several forms of human immunodeficiency virus type 1 (HIV-1) DNA in peripheral blood T cells and lymph nodes in untreated HIV-1-infected individuals and in patients whose plasma HIV-1 RNA levels are suppressed ...
    • Article  

      T cell receptor excision circles and HIV-1 2-LTR episomal DNA to predict AIDS in patients not receiving effective therapy 

      Goedert, J. J.; O'Brien, T. R.; Hatzakis, Angelos E.; Kostrikis, Leontios G. (2001)
      Objective: To determine whether improved prediction of AIDS-free survival following HIV-1 seroconversion is achieved by measuring HIV-1 2-LTR episomal DNA (2-LTR) circles and T cell receptor rearrangement excision circles ...